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GSH replenishment in human tissues is difficult due to its shorter half-life, and not easy to penetrate the plasma membrane hence use of prodrugs/precursors such as cysteine, and glycine is the most promising approach 4,45

The incomplete abolition of 3MP-induced H 2 S production and mt-roGFP2 oxidation in MST KO cells may be explained by the conversion of 3MP to Cys by CTA (Singh and Banerjee, 2011a), thereby allowing MST-independent H 2 S generation from 3MP

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Figure 2 3.1 Study characteristics and quality The nine publications evaluated included six clinical studies, two case series, and one survey